Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.51 |
| ▸ | ACACB | O00763 | 13/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | FPR2 | P25090 | 2/20 | 0.42 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7958655 | 0.88 | LIPG (0.50) | ACACBFPR2PROKR1 | |
| SCHEMBL7947314 | 0.84 | ACACB (0.46) | PDE3BPDE3AACACBPDE10A | |
| SCHEMBL7956152 | 0.83 | ACACB (0.52) | PDE3BPDE3AACACBPDE10A | |
| SCHEMBL7956861 | 0.82 | ACACB (0.51) | PDE3BPDE3AACACBPDE10A | |
| SCHEMBL7956662 | 0.82 | ACACB (0.55) | PDE3BPDE3AACACBKCNH2PDE10A | |
| SCHEMBL7961508 | 0.82 | ACACB (0.51) | PDE3BPDE3AACACBPDE10A | |
| SCHEMBL7955313 | 0.80 | ACACB (0.49) | PDE3BPDE3AACACBPDE10A | |
| SCHEMBL7961730 | 0.79 | ACACB (0.51) | PDE3BPDE3AACACBPDE10A | |
| SCHEMBL7956683 | 0.79 | HRH3 (0.58) | PDE3BPDE3AACACBPDE10A | |
| SCHEMBL7956968 | 0.79 | ABL1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |