Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYCR1 | P32322 | 1/20 | 0.43 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | LSS | P48449 | 2/20 | 0.40 |
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | EIF4E | P06730 | 1/20 | 0.38 |
| ▸ | GSTO1 | P78417 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.37 |
| ▸ | MPL | P40238 | 1/20 | 0.37 |
| ▸ | ATP4A | P20648 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7118149 | 0.87 | KDM4E (0.53) | PYCR1SREBF2RAB9ANPC1KDM4E | |
| SCHEMBL7671507 | 0.83 | EIF4E (0.48) | EIF4E | |
| SCHEMBL7669493 | 0.82 | RAB9A (0.53) | PYCR1SREBF2RAB9ANPC1KDM4E | |
| SCHEMBL7675100 | 0.81 | MAPT (0.56) | PYCR1SREBF2RAB9ANPC1TDP1 | |
| SCHEMBL8018616 | 0.79 | ATP4A (0.42) | PYCR1RAB9AKDM4EMAPTKMT2A | |
| SCHEMBL7678096 | 0.78 | MAPT (0.54) | PYCR1RAB9ANPC1TDP1SMN1; SMN2 | |
| SCHEMBL7535129 | 0.75 | EIF4E (0.47) | RAB9ANPC1TDP1SMN1; SMN2MAPT | |
| SCHEMBL25959114 | 0.73 | SREBF2 (0.69) | SREBF2RAB9ANPC1TDP1KDM4E | |
| SCHEMBL23742623 | 0.72 | RAB9A (0.63) | SREBF2RAB9ANPC1TDP1KDM4E | |
| SCHEMBL7788713 | 0.71 | THRB (0.44) | RAB9ANPC1SMN1; SMN2MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281217-B2 | ANTIFUNGAL ACTIVITY AGAINST A VARIETY OF FUNGI INCLUDING STRAINS WHICH HAVE PROVEN TO BE RESISTANT TO TREATMENT WITH KNOWN ANTIFUNGAL AGENTS SUCH AS FLUCONAZOLE. | YU DINGWEI TIM (US) | 2001-08-28 | — | — | US | disclosed |
| US-6277873-B1 | CONTROLLING DRUG RESISTANT FUNGI | YU DINGWEI TIM (US) | 2001-08-21 | — | — | US | disclosed |
| US-6156776-A | Diaryl substituted thiazoles useful in the treatment of fungal infections | YU DINGWEI TIM (US) | 2000-12-05 | — | — | US | disclosed |