Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.67 |
| ▸ | NPC1 | O15118 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | EDNRB | P24530 | 1/20 | 0.56 |
| ▸ | EDNRA | P25101 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27980886 | 0.79 | RAB9A (0.61) | RAB9ANPC1KMT2A | |
| SCHEMBL27934733 | 0.78 | MAOB (0.59) | RAB9ANPC1KMT2A | |
| SCHEMBL14759253 | 0.77 | AR (0.52) | RAB9ANPC1KMT2A | |
| SCHEMBL7954475 | 0.76 | EDNRB (0.71) | EDNRBEDNRA | |
| SCHEMBL27499329 | 0.75 | KDM4E (0.56) | RAB9AKMT2A | |
| SCHEMBL7943851 | 0.75 | EDNRB (0.76) | EDNRBEDNRA | |
| SCHEMBL7951769 | 0.75 | EDNRB (0.54) | EDNRBEDNRA | |
| SCHEMBL7943804 | 0.75 | EDNRB (0.87) | EDNRBEDNRA | |
| SCHEMBL27499330 | 0.75 | EDNRB (0.55) | EDNRB | |
| SCHEMBL12341996 | 0.74 | LMNA (0.52) | RAB9ANPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103271904-B | Nitric oxide donor endothelin receptor antagonist as well as preparation method and application thereof | UNIV SOUTHEAST | 2014-11-12 | — | — | CN | disclosed |
| CN-103271904-A | Nitric oxide donor endothelin receptor antagonist as well as preparation method and application thereof | UNIV SOUTHEAST | 2013-09-04 | — | — | CN | disclosed |
| US-6218427-B1 | AS ENDOTHELIN RECEPTOR ANTAGONIST | SHIONOGI & CO., LTD. (JP) | 2001-04-17 | — | — | US | disclosed |
| EP-0924207-A1 | CHROMENE-3-CARBOXYLATE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 1999-06-23 | — | — | EP | disclosed |