Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK2 | P25098 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 9/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.38 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14640459 | 0.84 | SLC6A4 (0.51) | GRK2SLC6A4SLC6A2SLC6A3HTR2B | |
| SCHEMBL7850673 | 0.84 | HTR3A (0.53) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL1945968 | 0.84 | GRK2 (0.56) | GRK2SLC6A4SLC6A2SLC6A3CYP3A4 | |
| SCHEMBL4429628 | 0.84 | GRK2 (0.56) | GRK2SLC6A4SLC6A2SLC6A3CYP3A4 | |
| SCHEMBL1096634 | 0.84 | GRK2 (0.56) | GRK2SLC6A4SLC6A2SLC6A3CYP3A4 | |
| SCHEMBL4428153 | 0.84 | GRK2 (0.56) | GRK2SLC6A4SLC6A2SLC6A3CYP3A4 | |
| SCHEMBL7035325 | 0.84 | GRK2 (0.56) | GRK2SLC6A4SLC6A2SLC6A3CYP3A4 | |
| SCHEMBL18619443 | 0.84 | SLC6A4 (0.51) | GRK2SLC6A4SLC6A2SLC6A3HTR2B | |
| SCHEMBL6946523 | 0.83 | SLC18A3 (0.48) | SLC6A4SLC6A2ADRA2CHTR2ASIGMAR1 | |
| SCHEMBL1095996 | 0.83 | SLC18A3 (0.48) | SLC6A4SLC6A2ADRA2CHTR2ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001002357-A2 | PROCESS FOR THE SYNTHESIS OF 4-(4'-FLUOROPHENYL)-PIPERIDINES | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-01-11 | — | — | WO | disclosed |