Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.49 |
| ▸ | RAB9A | P51151 | 9/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.49 |
| ▸ | RELA | Q04206 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | HTR7 | P34969 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963733 | 0.93 | HTR7 (0.54) | NPC1RAB9ASMN1; SMN2L3MBTL1NFKB1 | |
| Irampanel SCHEMBL678128 | 0.84 | HTR7 (0.63) | NPC1RAB9ASMN1; SMN2L3MBTL1NFKB1 | |
| Irampanel SCHEMBL6879876 | 0.83 | HTR7 (0.62) | NPC1RAB9ASMN1; SMN2L3MBTL1NFKB1 | |
| SCHEMBL5736045 | 0.81 | HTR7 (0.63) | NPC1RAB9ASMN1; SMN2L3MBTL1HTR7 | |
| SCHEMBL7955292 | 0.81 | TTR (0.55) | NPC1RAB9ASMN1; SMN2L3MBTL1NFKB1 | |
| SCHEMBL7962019 | 0.81 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2L3MBTL1NFKB1 | |
| SCHEMBL7964562 | 0.80 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2L3MBTL1NFKB1 | |
| SCHEMBL7956779 | 0.78 | HTR7 (0.52) | NPC1RAB9ASMN1; SMN2L3MBTL1HTR7 | |
| SCHEMBL7947855 | 0.78 | SMN1; SMN2 (0.58) | NPC1RAB9ASMN1; SMN2L3MBTL1NFKB1 | |
| SCHEMBL7962298 | 0.78 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6277872-B1 | ANTIISCHEMIC AGENTS; BRAIN DISORDERS | BOEHRINGER INGELHEIM KG (DE) | 2001-08-21 | — | — | US | disclosed |