Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.54 |
| ▸ | HTR1B | P28222 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 6/20 | 0.48 |
| ▸ | RAB9A | P51151 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.46 |
| ▸ | RELA | Q04206 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7957012 | 0.93 | NPC1 (0.49) | HTR7HTR1BBCHEACHENPC1 | |
| Irampanel SCHEMBL678128 | 0.88 | HTR7 (0.63) | HTR7NPC1RAB9AKDM4EHSD17B10 | |
| Irampanel SCHEMBL6879876 | 0.87 | HTR7 (0.62) | HTR7NPC1RAB9AKDM4EHSD17B10 | |
| SCHEMBL5736045 | 0.83 | HTR7 (0.63) | HTR7NPC1RAB9AKDM4EHSD17B10 | |
| SCHEMBL7955292 | 0.83 | TTR (0.55) | HTR7NPC1RAB9AKDM4EHSD17B10 | |
| SCHEMBL7947855 | 0.82 | SMN1; SMN2 (0.58) | HTR7NPC1RAB9AKDM4EHSD17B10 | |
| SCHEMBL7962298 | 0.82 | NPC1 (0.64) | BCHEACHENPC1RAB9AKDM4E | |
| SCHEMBL7958685 | 0.82 | NR1H4 (0.62) | BCHEACHENPC1RAB9AKDM4E | |
| SCHEMBL7956997 | 0.81 | DRD2 (0.58) | HTR7NPC1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL7958842 | 0.81 | NPC1 (0.56) | HTR7BCHEACHENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6277872-B1 | ANTIISCHEMIC AGENTS; BRAIN DISORDERS | BOEHRINGER INGELHEIM KG (DE) | 2001-08-21 | — | — | US | disclosed |