Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 4/20 | 0.40 |
| ▸ | CSNK1E | P49674 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GMNN | O75496 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | CMKLR1 | Q99788 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL7959510 | 0.80 | KDM4E (0.30) | KMT2AMEN1KDM4EGMNNALDH1A1 | |
| SCHEMBL8824404 | 0.80 | CSF1R (0.46) | CSNK1DCSNK1EKMT2AMEN1ALDH1A1 | |
| Iodide SCHEMBL7957248 | 0.76 | RECQL (0.36) | KDM4EALDH1A1HPGDGAATGFBR1 | |
| SCHEMBL4833839 | 0.75 | KMT2A (0.46) | CSNK1DCSNK1EKMT2AMEN1KDM4E | |
| SCHEMBL19998087 | 0.73 | ALDH1A1 (0.42) | KMT2AKDM4EALDH1A1LMNAMAPT | |
| SCHEMBL4833999 | 0.72 | ADORA3 (0.50) | KDM4EALDH1A1LMNAMAPTHPGD | |
| Iodide SCHEMBL7949135 | 0.70 | HTR2A (0.39) | KMT2AMEN1KDM4EGMNNALDH1A1 | |
| SCHEMBL19998085 | 0.69 | ALDH1A1 (0.42) | KMT2AMEN1KDM4EALDH1A1LMNA | |
| SCHEMBL2524316 | 0.67 | PTGS2 (0.45) | KMT2AMEN1KDM4EALDH1A1HPGD | |
| SCHEMBL16708793 | 0.65 | CSNK1E (0.59) | CSNK1DCSNK1ETGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |