Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.32 |
| ▸ | THRB | P10828 | 4/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL7959513 | 0.80 | — | — | |
| Iodide SCHEMBL7957246 | 0.76 | CSNK1D (0.40) | PTGS2PTGS1TGFBR1GAAKDM4E | |
| Iodide SCHEMBL7949138 | 0.70 | KDM5B (0.32) | DRD3 | |
| SCHEMBL8824404 | 0.67 | CSF1R (0.46) | PTGS2PTGS1ADRA1AGAAALDH1A1 | |
| SCHEMBL2524316 | 0.67 | PTGS2 (0.45) | PTGS2PTGS1TGFBR1THRBMAPK14 | |
| SCHEMBL2521875 | 0.63 | THRB (0.43) | PTGS2PTGS1TGFBR1THRBMAPK14 | |
| SCHEMBL2526666 | 0.63 | THRB (0.43) | PTGS2PTGS1TGFBR1THRBMAPK14 | |
| SCHEMBL4833839 | 0.62 | KMT2A (0.46) | PTGS2PTGS1TGFBR1THRBMAPK14 | |
| SCHEMBL19998087 | 0.61 | ALDH1A1 (0.42) | CHRM2CHRM1SLC6A2HRH3GAA | |
| SCHEMBL3109802 | 0.61 | ACVR1 (0.49) | TGFBR1THRBMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |