SCHEMBL7958352

SCHEMBL7958352

COC(=O)C(NC(=O)Cc1ccc(OC)cc1C)C(C)C

nearest known ligand 0.53

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.53
SMN1; SMN2 Q16637 1/20 0.51
THRB P10828 1/20 0.50
TAS1R3 Q7RTX0 1/20 0.48
TAS1R1 Q7RTX1 1/20 0.48
MEN1 O00255 5/20 0.45
KMT2A Q03164 5/20 0.45
NPSR1 Q6W5P4 1/20 0.43
CASP1 P29466 1/20 0.42
CASP3 P42574 1/20 0.42
CASP7 P55210 1/20 0.42
CASP8 Q14790 1/20 0.42
GAA P10253 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6988661 1.00 ALDH1A1 (0.53) ALDH1A1SMN1; SMN2THRBTAS1R3TAS1R1
SCHEMBL6996829 0.90 MEN1 (0.47) ALDH1A1THRBMEN1KMT2ANPSR1
SCHEMBL6996825 0.90 MEN1 (0.47) ALDH1A1THRBMEN1KMT2ANPSR1
SCHEMBL6996770 0.89 ALDH1A1 (0.56) ALDH1A1TAS1R3TAS1R1MEN1KMT2A
SCHEMBL7964516 0.89 ALDH1A1 (0.56) ALDH1A1TAS1R3TAS1R1MEN1KMT2A
SCHEMBL7961893 0.86 MEN1 (0.50) ALDH1A1MEN1KMT2A
SCHEMBL6995409 0.86 MEN1 (0.50) ALDH1A1MEN1KMT2A
SCHEMBL15925981 0.86 ALDH1A1 (0.65) ALDH1A1SMN1; SMN2THRBTAS1R3TAS1R1
SCHEMBL8657482 0.86 ALDH1A1 (0.57) ALDH1A1SMN1; SMN2THRBTAS1R3TAS1R1
SCHEMBL8557162 0.86 ALDH1A1 (0.57) ALDH1A1SMN1; SMN2THRBTAS1R3TAS1R1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6172255-B1 INSECTICIDES; MITICIDES BAYER AKTIENGESELLSCHAFT (DE) 2001-01-09 US disclosed
US-5830826-A Alkoxy-alkyl-substituted 1H-3-aryl-pyrrolidine-2, 4-diones used as herbicicides and pesticides BAYER AKTIENGESELLSCHAFT (DE) 1998-11-03 US disclosed