Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 6/20 | 0.46 |
| ▸ | METAP1 | P53582 | 3/20 | 0.43 |
| ▸ | ACHE | P22303 | 4/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4623245 | 0.79 | METAP1 (0.49) | MCHR1METAP1CYP19A1CYP26A1 | |
| Oxalic Acid SCHEMBL7958546 | 0.78 | MTNR1A (0.40) | ACHECA1CA2KDM4EALDH1A1 | |
| SCHEMBL7958545 | 0.75 | METAP1 (0.43) | MCHR1METAP1ACHECA1CA2 | |
| Hydrochloric Acid SCHEMBL4623292 | 0.71 | CYP19A1 (0.59) | MCHR1METAP1ACHECA1CA2 | |
| Hydrochloric Acid SCHEMBL4622581 | 0.71 | MCHR1 (0.59) | MCHR1METAP1ACHECA1CA2 | |
| Acetic Acid SCHEMBL10992625 | 0.69 | CPS1 (0.48) | ACHEKDM4EKMT2A | |
| SCHEMBL3241271 | 0.67 | GAA (0.57) | ACHECA1CA2ALDH1A1 | |
| SCHEMBL19644392 | 0.66 | SIRT1 (0.43) | KDM4EALDH1A1KMT2A | |
| SCHEMBL14440140 | 0.66 | MCHR1 (0.46) | MCHR1ACHE | |
| Hydrochloric Acid SCHEMBL4623037 | 0.65 | MCHR1 (0.46) | MCHR1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329389-B1 | HETEROCYCLIC AMINES AND DERIVATIVES, SOMATOSTATIN AND ANTIDIABETIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-12-11 | — | — | US | disclosed |