Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | CHKA | P35790 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL171845 | 0.86 | MAPT (0.63) | MAPTHTTSMN1; SMN2CHKALMNA | |
| SCHEMBL9673237 | 0.83 | MAPT (0.58) | MAPTHTTSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL9673663 | 0.81 | MAPT (0.56) | MAPTHTTSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL9671475 | 0.81 | MAPT (0.56) | MAPTHTTSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL7954966 | 0.80 | KDM4E (0.51) | SMN1; SMN2CHKAPOLBAKR1C3ADRB2 | |
| SCHEMBL12082812 | 0.78 | LMNA (0.69) | MAPTHTTSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL7956932 | 0.76 | HIF1A (0.50) | MAPTHTTSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL7956784 | 0.76 | HIF1A (0.50) | MAPTHTTSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL6323362 | 0.75 | ITGB3 (0.48) | MAPTHTTSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL7956788 | 0.75 | ITGB3 (0.48) | MAPTHTTSMN1; SMN2LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |
| EP-0880501-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997028128-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1997-08-07 | — | — | WO | disclosed |