Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5773495 | 0.75 | HTT (0.52) | MAPK1HTTNPC1ALDH1A1POLB | |
| SCHEMBL7958670 | 0.75 | NPY5R (0.43) | NPY5RALDH1A1HPGD | |
| SCHEMBL1123974 | 0.73 | MAPT (0.39) | NPSR1NPC1ALDH1A1POLBMAPT | |
| SCHEMBL9122461 | 0.71 | MAPT (0.47) | HTTALDH1A1MAPTKMT2ACYP1A2 | |
| SCHEMBL9126475 | 0.70 | ALDH1A1 (0.56) | MAPK1NPSR1HTTALDH1A1MAPT | |
| SCHEMBL17376374 | 0.70 | FFAR2 (0.43) | MAPK1NPSR1ALDH1A1MAPTMEN1 | |
| SCHEMBL17376514 | 0.70 | FFAR2 (0.43) | MAPK1NPSR1ALDH1A1MAPTMEN1 | |
| SCHEMBL6947517 | 0.69 | MEN1 (0.44) | NPY5RMAPK1HTTNPC1ALDH1A1 | |
| SCHEMBL7077196 | 0.68 | MAPT (0.43) | MAPK1NPSR1NPC1ALDH1A1POLB | |
| SCHEMBL14786602 | 0.65 | MAPT (0.38) | HTTNPC1ALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | disclosed |