Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 3/20 | 0.31 |
| ▸ | RXRB | P28702 | 3/20 | 0.31 |
| ▸ | RXRG | P48443 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.30 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8307319 | 0.80 | — | — | |
| SCHEMBL4442406 | 0.79 | SIRT2 (0.38) | SIRT2AKT1NPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL1363162 | 0.76 | SIRT2 (0.49) | SIRT2AKT1NPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4563793 | 0.76 | SIRT2 (0.35) | SIRT2AKT1NPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7514117 | 0.75 | SIRT2 (0.34) | SIRT2AKT1NPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4442084 | 0.75 | SIRT2 (0.34) | SIRT2AKT1NPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8307946 | 0.71 | ALDH1A1 (0.35) | SIRT2AKT1NPSR1ALDH1A1NOTUM | |
| SCHEMBL9848736 | 0.68 | SIRT2 (0.52) | SIRT2NPSR1ALDH1A1SMN1; SMN2NOTUM | |
| SCHEMBL7510444 | 0.68 | PTGS1 (0.34) | NOTUMRXRARXRBRXRGTLR8 | |
| SCHEMBL8303146 | 0.68 | CRHR1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6177452-B1 | ANTIDIABETIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-01-23 | — | — | US | disclosed |