Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 3/20 | 0.31 |
| ▸ | RXRB | P28702 | 3/20 | 0.31 |
| ▸ | RXRG | P48443 | 3/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4442406 | 0.93 | SIRT2 (0.38) | ALDH1A1NPSR1AKT1TARBP2SIRT2 | |
| SCHEMBL4563793 | 0.92 | SIRT2 (0.35) | ALDH1A1NPSR1AKT1TARBP2SIRT2 | |
| SCHEMBL4442084 | 0.91 | SIRT2 (0.34) | ALDH1A1NPSR1AKT1TARBP2SIRT2 | |
| SCHEMBL7514117 | 0.91 | SIRT2 (0.34) | ALDH1A1NPSR1AKT1TARBP2SIRT2 | |
| SCHEMBL8305905 | 0.86 | RXRA (0.45) | ALDH1A1RXRARXRBRXRGKDM4E | |
| SCHEMBL8303146 | 0.86 | CRHR1 (0.31) | CRHR1 | |
| SCHEMBL8303347 | 0.85 | NR4A2 (0.35) | ALDH1A1TARBP2RXRARXRBRXRG | |
| SCHEMBL8303834 | 0.85 | CYP1A2 (0.32) | ALDH1A1NPSR1CRHR1PTGS2KDM4E | |
| SCHEMBL8303845 | 0.85 | RXRA (0.41) | ALDH1A1RXRARXRBRXRGPTGS2 | |
| SCHEMBL7510444 | 0.81 | PTGS1 (0.34) | NOTUMRXRARXRBRXRGPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891340-A1 | OXAZOLE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036882-A1 | OXAZOLE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-10-09 | — | — | WO | disclosed |