Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | BRD2 | P25440 | 1/20 | 0.34 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.34 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7959537 | 0.90 | SLC6A4 (0.36) | SLC6A4KDM4EKMT2AALDH1A1BRD4 | |
| SCHEMBL7963460 | 0.86 | SMN1; SMN2 (0.40) | KMT2AALDH1A1LMNAUSP28NPC1 | |
| SCHEMBL27477789 | 0.86 | CCR5 (0.36) | SLC6A4KMT2AALDH1A1LMNAUSP28 | |
| SCHEMBL7963068 | 0.86 | USP28 (0.34) | SLC6A4KMT2AALDH1A1BRD4BRD2 | |
| SCHEMBL7963454 | 0.84 | USP28 (0.41) | SLC6A4KMT2AALDH1A1BRD4BRD2 | |
| SCHEMBL7948978 | 0.84 | ALDH1A1 (0.38) | SLC6A4ALDH1A1BRD4BRD2BRD3 | |
| SCHEMBL7959259 | 0.84 | KDM4E (0.43) | SLC6A4KDM4EKMT2AALDH1A1LMNA | |
| SCHEMBL7960480 | 0.83 | USP28 (0.35) | KMT2AALDH1A1LMNAUSP28MEN1 | |
| SCHEMBL7959896 | 0.82 | ALDH1A1 (0.37) | SLC6A4ALDH1A1BRD4BRD2BRD3 | |
| SCHEMBL7959344 | 0.82 | KDM4E (0.42) | SLC6A4KDM4EKMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6245761-B1 | NERVOUS SYSTEM, CARDIOVASCULAR AND RESPIRATORY SYSTEM DISORDERS | ELI LILLY AND COMPANY | 2001-06-12 | — | — | US | disclosed |
| EP-0789688-A4 | INDOLYL NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-11-19 | — | — | EP | disclosed |
| EP-0789688-A1 | INDOLYL NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-08-20 | — | — | EP | disclosed |
| WO-1997009308-A1 | INDOLYL NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-03-13 | — | — | WO | disclosed |