Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP28 | Q96RU2 | 2/20 | 0.35 |
| ▸ | CCR5 | P51681 | 7/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.32 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963460 | 0.85 | SMN1; SMN2 (0.40) | USP28ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL7963068 | 0.84 | USP28 (0.34) | USP28CCR5ALDH1A1LMNAMEN1 | |
| SCHEMBL27477789 | 0.84 | CCR5 (0.36) | USP28CCR5ALDH1A1LMNAMEN1 | |
| SCHEMBL7958892 | 0.83 | SLC6A4 (0.43) | USP28ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL7963454 | 0.83 | USP28 (0.41) | USP28ALDH1A1MEN1KMT2AUSP25 | |
| SCHEMBL7959896 | 0.81 | ALDH1A1 (0.37) | USP28ALDH1A1LMNAUSP25 | |
| SCHEMBL7959344 | 0.81 | KDM4E (0.42) | CCR5ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL28371996 | 0.80 | USP28 (0.40) | USP28CCR5ALDH1A1MEN1KMT2A | |
| SCHEMBL7948978 | 0.79 | ALDH1A1 (0.38) | USP28ALDH1A1LMNAUSP25 | |
| SCHEMBL7959259 | 0.79 | KDM4E (0.43) | CCR5ALDH1A1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6245761-B1 | NERVOUS SYSTEM, CARDIOVASCULAR AND RESPIRATORY SYSTEM DISORDERS | ELI LILLY AND COMPANY | 2001-06-12 | — | — | US | disclosed |
| CN-1173867-A | Indolyl neuropeptide Y receptor antagonists | LILLY CO ELI (US) | 1998-02-18 | — | — | CN | disclosed |
| EP-0789688-A4 | INDOLYL NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-11-19 | — | — | EP | disclosed |
| EP-0789688-A1 | INDOLYL NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-08-20 | — | — | EP | disclosed |
| WO-1997009308-A1 | INDOLYL NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-03-13 | — | — | WO | disclosed |