Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | PTPRB | P23467 | 1/20 | 0.47 |
| ▸ | ACP1 | P24666 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4658121 | 0.81 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2LMNAPTPN2PTPN1 | |
| SCHEMBL6380611 | 0.80 | MEN1 (0.57) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL4442846 | 0.79 | KMT2A (0.60) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL10655573 | 0.79 | ITGB3 (0.60) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL10654800 | 0.79 | ITGB3 (0.60) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL28199355 | 0.79 | ITGB3 (0.60) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL843747 | 0.79 | MEN1 (0.57) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL7271033 | 0.78 | KMT2A (0.52) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL28199962 | 0.78 | MEN1 (0.52) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL28199963 | 0.78 | MEN1 (0.52) | MEN1KMT2ANPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271238-B1 | USEFUL IN TREATING AND PREVENTING DISEASES INVOLVING CHYMOTRYPSIN TYPE PROTEASES WHICH ARE RELATED TO ASTHMA, ALLERGY, INFLAMMATIONS, RHEUMATISM, HYPERTENSION, HEART FAILURE, MYOCARDIAL INFARCTION, AND CARDIAC HYPERTROPHY | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2001-08-07 | — | — | US | disclosed |
| EP-0936216-A1 | NOVEL ACETAMIDE DERIVATIVES AND PROTEASE INHIBITORS | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1999-08-18 | — | — | EP | disclosed |