Bromide

Bromide

SCHEMBL7959477

Br.Nc1ccccc1-c1cscn1.O

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.43
L3MBTL1 Q9Y468 2/20 0.43
IDO1 P14902 6/20 0.41
TDO2 P48775 3/20 0.40
KDM4E B2RXH2 3/20 0.39
NPC1 O15118 3/20 0.39
METAP2 P50579 3/20 0.39
RAB9A P51151 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
TDP1 Q9NUW8 2/20 0.39
METAP1 P53582 2/20 0.39
ADORA3 P0DMS8 2/20 0.39
TP53 P04637 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2D6 P10635 1/20 0.39
TSHR P16473 1/20 0.39
CYP2C19 P33261 1/20 0.39
FKBP1A P62942 1/20 0.39
HIF1A Q16665 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6765946 0.96 ALDH1A1 (0.43) ALDH1A1L3MBTL1IDO1TDO2KDM4E
SCHEMBL1800346 0.96 ALDH1A1 (0.46) ALDH1A1L3MBTL1IDO1TDO2KDM4E
SCHEMBL27703501 0.81 SCN9A (0.38) ALDH1A1L3MBTL1IDO1TDO2KDM4E
SCHEMBL20723607 0.79 TSHR (0.43) ALDH1A1L3MBTL1IDO1TDO2KDM4E
SCHEMBL1868592 0.79 SCN9A (0.40) IDO1TDO2KDM4ENPC1METAP2
SCHEMBL4518539 0.75 LMNA (0.53) ALDH1A1IDO1TDO2KDM4ENPC1
SCHEMBL27703498 0.74 METAP2 (0.49) IDO1TDO2KDM4ENPC1METAP2
SCHEMBL26259974 0.74 SCN9A (0.43) ALDH1A1IDO1TDO2KDM4ENPC1
SCHEMBL26259959 0.74 METAP2 (0.44) ALDH1A1IDO1TDO2KDM4ENPC1
SCHEMBL5966314 0.74 SCN9A (0.45) ALDH1A1IDO1TDO2KDM4ENPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0743574-B1 Migration imaging members XEROX CORP (US) 2000-12-27 EP claimed
EP-0743573-B1 Method for obtaining image contrast migration imaging members XEROX CORP (US) 2000-09-06 EP claimed
EP-0743573-A2 Method for obtaining image contrast migration imaging members XEROX CORPORATION (US) 1996-11-20 EP claimed
EP-0743574-A2 Migration imaging members XEROX CORPORATION (US) 1996-11-20 EP claimed
US-5563014-A SOFTENABLE LAYER CONTAINIG PHOTOSENSITIVE MARKING MATERIAL; TRANSPARENTIZING AGENT XEROX CORPORATION (US) 1996-10-08 US claimed
US-5514505-A SELECTIVE TRANSPARENTIZATION OF PHOTOSENSITIVE MIGRATION MARKING PARTICLES EMBEDDED NEAR THE SURFACE OF A SOFTENABLE LAYER SUPPORTED BY AN ELECTROCONDUCTIVE SUBSTRATE XEROX CORPORATION (US) 1996-05-07 US claimed
US-6180238-B1 PARTICULARLY SUITABLE FOR USE IN INK JET PRINTING PROCESSES. XEROX CORPORATION 2001-01-30 US disclosed
EP-0743574-B1 Migration imaging members XEROX CORP (US) 2000-12-27 EP disclosed
EP-0743573-B1 Method for obtaining image contrast migration imaging members XEROX CORP (US) 2000-09-06 EP disclosed
EP-0673784-B1 Recording sheets containing oxazole, isooxazole, oxazolidinone, oxazoline salts, morpholine, thiazole, thiazolidine, thiadiazole, and phenothiazine compounds XEROX CORP (US) 1999-10-27 EP disclosed
US-5729266-A Recording sheets containing oxazole, isooxazole, oxazolidinone, oxazoline salt, morpholine, thiazole, thiazolidine, thiadiazole and phenothiazine compounds XEROX CORPORATION (US) 1998-03-17 US disclosed
US-5635322-A Process for developing and overcoating migration imaging members XEROX CORPORTION (US) 1997-06-03 US disclosed
US-5580689-A SOLFTENABLE LAYER OF SOFTENABLE MATERIAL, PIGMENT SENSITIVE TO INFRARED OR RED LIGHT ILLUMINATION, AND MIGRATION MARKING MATERIAL XEROX CORPORATION (US) 1996-12-03 US disclosed
EP-0743573-A2 Method for obtaining image contrast migration imaging members XEROX CORPORATION (US) 1996-11-20 EP disclosed
EP-0743574-A2 Migration imaging members XEROX CORPORATION (US) 1996-11-20 EP disclosed
US-5563014-A SOFTENABLE LAYER CONTAINIG PHOTOSENSITIVE MARKING MATERIAL; TRANSPARENTIZING AGENT XEROX CORPORATION (US) 1996-10-08 US disclosed
US-5534374-A Migration imaging members XEROX CORPORATION (US) 1996-07-09 US disclosed
US-5514505-A SELECTIVE TRANSPARENTIZATION OF PHOTOSENSITIVE MIGRATION MARKING PARTICLES EMBEDDED NEAR THE SURFACE OF A SOFTENABLE LAYER SUPPORTED BY AN ELECTROCONDUCTIVE SUBSTRATE XEROX CORPORATION (US) 1996-05-07 US disclosed
EP-0673784-A2 Recording sheets containing oxazole, isooxazole, oxazolidinone, oxazoline salts, morpholine, thiazole, thiazolidine, thiadiazole, and phenothiazine compounds XEROX CORPORATION (US) 1995-09-27 EP disclosed