Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.52 |
| ▸ | DRD2 | P14416 | 10/20 | 0.49 |
| ▸ | DRD3 | P35462 | 10/20 | 0.49 |
| ▸ | HTR1A | P08908 | 8/20 | 0.49 |
| ▸ | HTR2A | P28223 | 6/20 | 0.49 |
| ▸ | DRD1 | P21728 | 6/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.49 |
| ▸ | DRD5 | P21918 | 3/20 | 0.49 |
| ▸ | HTR2C | P28335 | 3/20 | 0.48 |
| ▸ | HRH1 | P35367 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7961169 | 0.88 | MAPT (0.45) | DRD2HTR1AHTR1DHTR1BSLC6A4 | |
| SCHEMBL7961060 | 0.88 | HTR1A (0.54) | SIGMAR1DRD2DRD3HTR1AHTR2A | |
| SCHEMBL7959526 | 0.88 | MPO (0.55) | SIGMAR1DRD2HTR1AHTR1DHTR1B | |
| SCHEMBL5414463 | 0.81 | MPO (0.47) | SIGMAR1DRD2HTR1AHTR2AHRH1 | |
| SCHEMBL5396500 | 0.80 | MAPT (0.49) | SIGMAR1DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL5402430 | 0.79 | HTR1D (0.45) | SIGMAR1DRD2HTR1AKDM4EHTR1D | |
| SCHEMBL6613728 | 0.77 | SIGMAR1 (0.44) | SIGMAR1DRD2HTR1AHTR1DHTR1B | |
| SCHEMBL7957648 | 0.77 | SIGMAR1 (0.52) | SIGMAR1DRD2DRD3HTR1AHTR2A | |
| SCHEMBL7960945 | 0.76 | HTR1A (0.55) | SIGMAR1DRD2DRD3HTR1AHTR2A | |
| SCHEMBL6601965 | 0.75 | SPHK1 (0.40) | DRD2HTR1AHTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |