Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 15/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963861 | 0.92 | DRD2 (0.53) | DRD2SIGMAR1KDM4ELMNAMAPT | |
| SCHEMBL7961488 | 0.88 | DRD2 (0.64) | DRD2SIGMAR1HTR1APPARGPPARA | |
| SCHEMBL7964089 | 0.86 | DRD2 (0.64) | DRD2SIGMAR1HTR1A | |
| SCHEMBL7957393 | 0.85 | DRD2 (0.50) | DRD2SIGMAR1KDM4ELMNAMAPT | |
| SCHEMBL7959610 | 0.85 | SIGMAR1 (0.48) | DRD2SIGMAR1HTR1APPARGPPARA | |
| SCHEMBL7949597 | 0.83 | DRD2 (0.51) | DRD2SIGMAR1KDM4ELMNAMAPT | |
| SCHEMBL7963788 | 0.82 | SIGMAR1 (0.52) | DRD2SIGMAR1KDM4EMAPTHTR1A | |
| SCHEMBL7964138 | 0.82 | DRD2 (0.54) | DRD2SIGMAR1PPARGPPARA | |
| SCHEMBL7961374 | 0.81 | SIGMAR1 (0.57) | DRD2SIGMAR1KDM4EMAPT | |
| SCHEMBL7961334 | 0.81 | SIGMAR1 (0.57) | DRD2SIGMAR1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |