Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.64 |
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.62 |
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963788 | 0.89 | SIGMAR1 (0.52) | DRD2SIGMAR1HTR1APARP1 | |
| SCHEMBL7961374 | 0.88 | SIGMAR1 (0.57) | DRD2SIGMAR1 | |
| SCHEMBL7961488 | 0.88 | DRD2 (0.64) | DRD2SIGMAR1HTR1A | |
| SCHEMBL7959614 | 0.86 | DRD2 (0.56) | DRD2SIGMAR1HTR1A | |
| SCHEMBL7963861 | 0.86 | DRD2 (0.53) | DRD2SIGMAR1 | |
| SCHEMBL7957221 | 0.85 | SIGMAR1 (0.55) | DRD2SIGMAR1HTR1APARP1 | |
| SCHEMBL7961334 | 0.83 | SIGMAR1 (0.57) | DRD2SIGMAR1HTR1A | |
| SCHEMBL7964085 | 0.81 | SIGMAR1 (0.55) | DRD2SIGMAR1HTR1APARP1CYP2D6 | |
| SCHEMBL8010714 | 0.81 | SIGMAR1 (0.72) | DRD2SIGMAR1PARP1 | |
| SCHEMBL6367176 | 0.81 | DRD2 (0.61) | DRD2SIGMAR1HTR1APARP1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |