SCHEMBL7964138

SCHEMBL7964138

CCOC(=O)CCCN1CC=C(c2ccc(F)c(Cl)c2)CC1

nearest known ligand 0.54

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 1/20 0.54
SIGMAR1 Q99720 13/20 0.52
SUV39H2 Q9H5I1 2/20 0.49
PPARG P37231 4/20 0.49
PPARA Q07869 4/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7961255 0.92 DRD2 (0.52) DRD2SIGMAR1SUV39H2PPARGPPARA
SCHEMBL7957644 0.88 DRD2 (0.61) DRD2SIGMAR1PPARGPPARA
SCHEMBL8570913 0.86 PPARG (0.54) DRD2SIGMAR1SUV39H2PPARGPPARA
SCHEMBL7963688 0.85 DRD2 (0.47) DRD2SIGMAR1SUV39H2PPARGPPARA
SCHEMBL7961282 0.85 SIGMAR1 (0.52) DRD2SIGMAR1SUV39H2PPARGPPARA
SCHEMBL7949222 0.84 DRD2 (0.49) DRD2SIGMAR1SUV39H2PPARGPPARA
SCHEMBL7959741 0.82 SIGMAR1 (0.55) DRD2SIGMAR1SUV39H2PPARGPPARA
SCHEMBL7959358 0.82 SIGMAR1 (0.55) DRD2SIGMAR1SUV39H2PPARGPPARA
SCHEMBL7959614 0.82 DRD2 (0.56) DRD2SIGMAR1PPARGPPARA
SCHEMBL7957384 0.81 SIGMAR1 (0.55) DRD2SIGMAR1SUV39H2PPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6187774-B1 N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 2001-02-13 US disclosed
EP-0885883-A1 FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1998-12-23 EP disclosed