Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.46 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.46 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23295626 | 0.81 | IDH1 (0.44) | ALDH1A1KDM4ETSHRCYP3A4 | |
| SCHEMBL2574713 | 0.75 | CYP2D6 (0.46) | SMN1; SMN2AOC3MAOAMAOB | |
| SCHEMBL31357517 | 0.75 | CYP2D6 (0.46) | SMN1; SMN2AOC3MAOAMAOB | |
| Dibemethine SCHEMBL10542007 | 0.74 | ALDH1A1 (0.70) | ALDH1A1KDM4ESMN1; SMN2CARM1PRMT6 | |
| Dibemethine SCHEMBL276863 | 0.74 | ALDH1A1 (0.70) | ALDH1A1KDM4ESMN1; SMN2CARM1PRMT6 | |
| SCHEMBL19082589 | 0.73 | ALDH1A1 (0.56) | ALDH1A1KDM4ESMN1; SMN2CARM1PRMT6 | |
| Dibemethine SCHEMBL2139708 | 0.72 | ALDH1A1 (0.67) | ALDH1A1KDM4ESMN1; SMN2CARM1PRMT6 | |
| SCHEMBL3152066 | 0.71 | CARM1 (0.59) | ALDH1A1KDM4ESMN1; SMN2CARM1PRMT6 | |
| SCHEMBL27858491 | 0.70 | IDH1 (0.46) | ALDH1A1KDM4ESMN1; SMN2TSHRCYP3A4 | |
| SCHEMBL10886152 | 0.69 | CD44 (0.42) | ALDH1A1KDM4ESMN1; SMN2TSHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997046539-A1 | AMIDE DERIVATIVES OF SUBSTITUTED QUINOXALINE 2,3-DIONES AS GLUTAMATE RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1997-12-11 | — | — | WO | claimed |
| US-6268366-B1 | Amide derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists | WARNER-LAMBERT COMPANY | 2001-07-31 | — | — | US | disclosed |
| US-6191134-B1 | STROKE THERAPY, ANTIISCHEMIC AGENTS, BRAIN DISORDERS | WARNER-LAMBERT COMPANY | 2001-02-20 | — | — | US | disclosed |
| US-6172065-B1 | CENTRAL NERVOUS SYSTEM DISORDERS | WARNER-LAMBERT COMPANY | 2001-01-09 | — | — | US | disclosed |
| US-6096744-A | ANTICONVULSANTS | WARNER-LAMBERT COMPANY (US) | 2000-08-01 | — | — | US | disclosed |
| US-6063774-A | NERVOUS SYSTEM DISORDERS | WARNER-LAMBERT COMPANY (US) | 2000-05-16 | — | — | US | disclosed |
| WO-1998027097-A1 | TRICYCLIC QUINOXALINE DERIVATIVES AS NEUROPROTECTIVE AGENTS | WARNER-LAMBERT COMPANY (US) | 1998-06-25 | — | — | WO | disclosed |