Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | ADCY10 | Q96PN6 | 4/20 | 0.32 |
| ▸ | MPO | P05164 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14840998 | 0.69 | LTB4R (0.46) | KDM4EALDH1A1LMNAGLAHPGD | |
| SCHEMBL7960340 | 0.69 | ALDH1A1 (0.38) | KDM4EALDH1A1GLAHPGDSMN1; SMN2 | |
| SCHEMBL4060963 | 0.62 | ALDH1A1 (0.43) | KDM4EALDH1A1GLAHPGDLTB4R | |
| SCHEMBL4064971 | 0.61 | ADORA2A (0.42) | KDM4EALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL27907274 | 0.59 | KDM4E (0.43) | KDM4EALDH1A1LMNAGLAHPGD | |
| SCHEMBL16399558 | 0.58 | ALDH1A1 (0.46) | KDM4EALDH1A1LMNAGLAHPGD | |
| SCHEMBL10516437 | 0.58 | LTB4R (0.47) | ALDH1A1LTB4RCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10258111 | 0.58 | RAB9A (0.46) | KDM4EALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL10257456 | 0.58 | TSHR (0.38) | KDM4EALDH1A1HPGDLTB4RCYP1A2 | |
| SCHEMBL21306242 | 0.57 | CALM1 (0.61) | KDM4EALDH1A1HPGDLTB4RCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014045310-A1 | PYRIMIDO[5,4-D]PYRIMIDINE OR PYRIMIDINE DERIVATIVES COMPOUNDS AND USES THEREOF IN THE TREATMENT OF CANCER | ZOLLO MASSIMO (IT) | 2014-03-27 | — | — | WO | claimed |
| WO-2014045310-A1 | PYRIMIDO[5,4-D]PYRIMIDINE OR PYRIMIDINE DERIVATIVES COMPOUNDS AND USES THEREOF IN THE TREATMENT OF CANCER | ZOLLO MASSIMO (IT) | 2014-03-27 | — | — | WO | disclosed |
| US-6297250-B1 | USEFUL FOR INHIBITING TRANSPORT OF NUCLEOSIDES OR PURINES ACROSS CELL MEMBRANES, THEREBY TO POTENTIATE THE ACTIVITY OF VARIOUS CYTOTOXIC ANTITUMOR DRUGS | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 2001-10-02 | — | — | US | disclosed |