Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7597748 | 0.98 | CHRM2 (0.44) | CHRM2GAAMAPTTSHRMAPK1 | |
| SCHEMBL7598124 | 0.87 | SMN1; SMN2 (0.48) | GAAMAPTTSHRMAPK1HTT | |
| SCHEMBL6269217 | 0.83 | PRKCI (0.43) | GAAMAPTTSHRMAPK1HTT | |
| Hydrochloric Acid SCHEMBL6848904 | 0.82 | ACHE (0.45) | GAAMAPTHTTKDM4EALDH1A1 | |
| SCHEMBL3813395 | 0.80 | SLC6A4 (0.56) | GAAMAPTTSHRMAPK1HTT | |
| SCHEMBL13244224 | 0.79 | ALDH1A1 (0.46) | GAAMAPTTSHRMAPK1HTT | |
| SCHEMBL8705108 | 0.79 | CHRM2 (0.71) | CHRM2MAPTAOC3APPALDH1A1 | |
| SCHEMBL27685404 | 0.78 | MAPT (0.52) | GAAMAPTTSHRMAPK1HTT | |
| SCHEMBL216813 | 0.78 | MAPT (0.55) | GAAMAPTTSHRMAPK1HTT | |
| SCHEMBL30780911 | 0.78 | MAPT (0.55) | GAAMAPTTSHRMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001046171-A1 | AMIDINE DERIVATIVES WHICH ARE INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRAZENECA AB (SE) | 2001-06-28 | — | — | WO | disclosed |