Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KCNA3 | P22001 | 6/20 | 0.38 |
| ▸ | KCNN4 | O15554 | 5/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 3/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | TGM2 | P21980 | 1/20 | 0.35 |
| ▸ | CDC25B | P30305 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10246639 | 0.79 | LMNA (0.45) | NOTUMKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL20622381 | 0.76 | KMT2A (0.50) | NOTUMKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL28855145 | 0.74 | NOTUM (0.58) | NOTUMKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL30776885 | 0.74 | NOTUM (0.58) | NOTUMKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL6366299 | 0.74 | NOTUM (0.58) | NOTUMKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL3940567 | 0.71 | NPC1 (0.52) | NOTUMKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL6126239 | 0.69 | NOTUM (0.53) | NOTUMKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL6360254 | 0.69 | NOTUM (0.53) | NOTUMKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL1048074 | 0.69 | NOTUM (1.00) | NOTUMKDM4EALDH1A1KCNA3KCNN4 | |
| SCHEMBL14516311 | 0.69 | NOTUM (0.53) | NOTUMKMT2AMEN1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015585-A1 | 6-BENZYL-2,3,4,7-TETRAHYDRO-INDOLO[2,3-C]QUINOLINE COMPOUNDS | NYCOMED GMBH (DE) | 2010-02-11 | — | — | WO | disclosed |
| WO-2010015588-A1 | BENZYL-SUBSTITUTED TETRACYCLIC HETEROCYCLIC COMPOUNDS | NYCOMED GMBH (DE) | 2010-02-11 | — | — | WO | disclosed |