Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.58 |
| ▸ | CES1 | P23141 | 5/20 | 0.45 |
| ▸ | TTR | P02766 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 2/20 | 0.44 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.41 |
| ▸ | KCNA3 | P22001 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.40 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.39 |
| ▸ | CDC25A | P30304 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30776885 | 1.00 | NOTUM (0.58) | NOTUMCES1TTRBCHEKCNN4 | |
| SCHEMBL69754 | 0.79 | NOTUM (0.46) | NOTUMCES1TTRBCHEKMT2A | |
| SCHEMBL26487743 | 0.78 | CASP3 (0.47) | NOTUMCES1TTRBCHEKCNN4 | |
| SCHEMBL14408830 | 0.76 | MEN1 (0.50) | NOTUMCES1TTRBCHEKMT2A | |
| SCHEMBL29960722 | 0.76 | MEN1 (0.50) | NOTUMCES1TTRBCHEKMT2A | |
| SCHEMBL86299 | 0.76 | MAOA (0.50) | CES1TTRBCHEKMT2AALDH1A1 | |
| SCHEMBL7421554 | 0.75 | CES1 (0.47) | NOTUMCES1TTRBCHEALDH1A1 | |
| SCHEMBL9025184 | 0.75 | CASP3 (0.46) | NOTUMCES1TTRBCHEKMT2A | |
| SCHEMBL3800178 | 0.74 | KMT2A (0.42) | KMT2AALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL7960787 | 0.74 | NOTUM (0.53) | NOTUMCES1TTRBCHEKCNN4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230399338-A1 | METHOD OF SYNTHESIZING (3S,3AR,5R,7AS,8S)- HEXAHYDRO-4H-3,5-METHANOFURO[2,3-b]PYRAN-8-OL | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-12-14 | — | — | US | disclosed |
| CN-115745825-A | Method for catalyzing amide alkylation reaction by using tridentate NNO nickel complex | 浙江工业大学 | 2023-03-07 | — | — | CN | disclosed |
| CN-114920728-A | Methylidine derivative and preparation method and application thereof | 中南大学 | 2022-08-19 | — | — | CN | disclosed |
| CN-111205202-A | Quaternary carbon center-containing symmetric gem-difluoroolefin derivative and synthesis method thereof | 华南理工大学 | 2020-05-29 | — | — | CN | disclosed |
| US-9758480-B2 | 1-(cycloalkyl-carbonyl)proline derivative | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2017-09-12 | — | — | US | disclosed |
| US-9758480-B2 | 1-(cycloalkyl-carbonyl)proline derivative | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2017-09-12 | — | — | US | disclosed |
| US-9670225-B2 | HIV-1 protease inhibitors and uses thereof | PURDUE RESEARCH FOUNDATION (US) | 2017-06-06 | — | — | US | disclosed |
| US-20170088555-A1 | HIV-1 PROTEASE INHIBITORS AND USES THEREOF | PURDUE RESEARCH FOUNDATION | 2017-03-30 | — | — | US | disclosed |
| EP-1317013-B1 | NON-AQUEOUS ELECTROLYTE AND SECONDARY CELL USING THE SAME | MITSUBISHI CHEM CORP (JP) | 2017-03-15 | — | — | EP | disclosed |
| US-20160318933-A1 | FUSED PYRAZOLE DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2016-11-03 | — | — | US | disclosed |
| WO-2013118805-A1 | 3-SUBSTITUTED PROLINE DERIVATIVE | 大日本住友製薬株式会社 (JP) | 2013-08-15 | — | — | WO | disclosed |
| US-20100120730-A1 | 6-BENZYL-2,3,4,7-TETRAHYDRO-INDOLO [2,3-C] QUINOLINE COMPOUNDS USEFUL AS PDE5 INHIBITORS | NYCOMED GMBH (DE) | 2010-05-13 | — | — | US | disclosed |
| US-7666865-B2 | for treating pain; STROKES; ANALGESICS; do not contain substituents that are antioxidants, tropolones or coumarins | NEUROMED PHARMACEUTICALS LTD. (CA) | 2010-02-23 | — | — | US | disclosed |
| US-7666865-B2 | for treating pain; STROKES; ANALGESICS; do not contain substituents that are antioxidants, tropolones or coumarins | NEUROMED PHARMACEUTICALS LTD. (CA) | 2010-02-23 | — | — | US | disclosed |
| US-20070185105-A1 | Calcium channel blockers | ZALICUS PHARMACEUTICALS LTD. (CA) | 2007-08-09 | — | — | US | disclosed |
| US-20070185105-A1 | Calcium channel blockers | ZALICUS PHARMACEUTICALS LTD. (CA) | 2007-08-09 | — | — | US | disclosed |
| US-6942948-B2 | Nonaqueous electrolyte solution and secondary battery employing the same | MITSUBISHI CHEMICAL CORPORATION (JP) | 2005-09-13 | — | — | US | disclosed |
| EP-1466605-A2 | Calcium channel blockers | Neuromed Technologies Inc. (CA) | 2004-10-13 | — | — | EP | disclosed |
| US-20030165733-A1 | Nonaqueous electrolyte solution and secondary battery employing the same | MITSUBISHI CHEMICAL CORPORATION (JP) | 2003-09-04 | — | — | US | disclosed |
| EP-1317013-A1 | NON-AQUEOUS ELECTROLYTE AND SECONDARY CELL USING THE SAME | MITSUBISHI CHEMICAL CORPORATION (JP) | 2003-06-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185105-A1 | Calcium channel blockers | CACNA1S, KCNN4, CACNA1C | NOTUM 2104/4885CES1 722/4885TTR 3869/4885 |
| US-20230399338-A1 | METHOD OF SYNTHESIZING (3S,3AR,5R,7AS,8S)- HEXAHYDRO-4H-3,5-METHANOFURO[2,3-b]PYRAN-8-OL | HTR3C, CYP2S1, CYP4F8 | NOTUM 1090/4885CES1 1020/4885TTR 2371/4885 |
| US-20160318933-A1 | FUSED PYRAZOLE DERIVATIVE | DRD4, DRD2, DRD3 | NOTUM 3877/4885CES1 3464/4885TTR 4799/4885 |
| US-20100120730-A1 | 6-BENZYL-2,3,4,7-TETRAHYDRO-INDOLO [2,3-C] QUINOLINE COMPOUNDS USEFUL AS PDE5 INHIBITORS | PDE5A, PDE3A, PDE2A | NOTUM 803/4885CES1 398/4885TTR 4865/4885 |
| US-20170088555-A1 | HIV-1 PROTEASE INHIBITORS AND USES THEREOF | PRSS1, XPNPEP1, CTRL | NOTUM 2161/4885CES1 86/4885TTR 1885/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.