Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 12/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7957644 | 0.92 | DRD2 (0.61) | SIGMAR1DRD2HTR1APPARGPPARA | |
| SCHEMBL7959741 | 0.92 | SIGMAR1 (0.55) | SIGMAR1DRD2S1PR1S1PR3PPARG | |
| SCHEMBL7957384 | 0.91 | SIGMAR1 (0.55) | SIGMAR1DRD2S1PR1S1PR3PPARG | |
| SCHEMBL18937665 | 0.89 | QDPR (0.50) | SIGMAR1DRD2S1PR1S1PR3PPARG | |
| SCHEMBL7959358 | 0.87 | SIGMAR1 (0.55) | SIGMAR1DRD2HTR1AS1PR1S1PR3 | |
| SCHEMBL7964138 | 0.85 | DRD2 (0.54) | SIGMAR1DRD2PPARGPPARASUV39H2 | |
| SCHEMBL7961255 | 0.85 | DRD2 (0.52) | SIGMAR1DRD2PPARGPPARASUV39H2 | |
| SCHEMBL8570913 | 0.84 | PPARG (0.54) | SIGMAR1DRD2PPARGPPARASUV39H2 | |
| SCHEMBL17107436 | 0.83 | PPARG (0.42) | SIGMAR1DRD2S1PR1S1PR3PPARG | |
| SCHEMBL17107417 | 0.83 | PPARG (0.42) | SIGMAR1DRD2S1PR1S1PR3PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |