Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 3/20 | 0.42 |
| ▸ | CCND1 | P24385 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8122423 | 0.81 | CRHR1 (0.55) | CRHR1KDM4EHPGDHSD17B10CDK4 | |
| SCHEMBL7928892 | 0.80 | KDM4E (0.49) | CRHR1KDM4EHPGDHSD17B10CDK4 | |
| SCHEMBL7961654 | 0.74 | CRHR1 (0.54) | CRHR1KDM4EHPGDCDK4CCND1 | |
| SCHEMBL7937119 | 0.74 | CRHR1 (0.46) | CRHR1KDM4EHPGDHSD17B10CDK4 | |
| SCHEMBL5620424 | 0.73 | CRHR1 (0.47) | CRHR1CDK4CCND1 | |
| SCHEMBL7935049 | 0.67 | CRHR1 (0.47) | CRHR1LMNA | |
| SCHEMBL5826757 | 0.67 | CDK4 (0.54) | KDM4EHPGDHSD17B10CDK4CCND1 | |
| SCHEMBL7935053 | 0.66 | ALDH1A1 (0.50) | CRHR1KDM4EHPGDHSD17B10CDK4 | |
| SCHEMBL7354421 | 0.66 | CRHR1 (0.54) | CRHR1 | |
| SCHEMBL5599759 | 0.66 | CRHR1 (0.87) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248753-B1 | CORTICOTROPIN-RELEASING FACTOR (CRF) ANTAGONISTS | PFIZER INC | 2001-06-19 | — | — | US | disclosed |
| EP-0765327-B1 | PYRAZOLO AND PYRROLOPYRIDINES | PFIZER (US) | 1999-07-21 | — | — | EP | disclosed |