Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23643511 | 0.90 | NFKB1 (0.52) | TTRHSD17B10ALDH1A1CYP3A4TSHR | |
| SCHEMBL23643400 | 0.86 | TTR (0.38) | TTRHSD17B10ALDH1A1CYP3A4TSHR | |
| SCHEMBL655459 | 0.74 | AURKA (0.61) | GSK3BGSK3ASLKAURKA | |
| SCHEMBL2087642 | 0.73 | BACE1 (0.42) | RECQLMAPTMEN1MAPK1KMT2A | |
| SCHEMBL7960772 | 0.73 | CYP3A4 (0.44) | TTRHSD17B10ALDH1A1CYP3A4TSHR | |
| SCHEMBL17108185 | 0.71 | TTR (0.46) | TTRHSD17B10ALDH1A1CYP3A4TSHR | |
| SCHEMBL8973726 | 0.71 | NFKB1 (0.55) | TSHRMAPTMEN1MAPK1KMT2A | |
| SCHEMBL10869800 | 0.70 | NPC1 (0.46) | ALDH1A1MAPTMEN1MAPK1KMT2A | |
| SCHEMBL23643419 | 0.70 | NFKB1 (0.53) | MAPTMEN1MAPK1KMT2AAPP | |
| SCHEMBL10429500 | 0.70 | NPY5R (0.50) | MAPTMEN1KMT2AAPPGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262053-B1 | EFFECTIVE FOR TREATING TUMOR CELLS AND PARTICULARLY EFFECTIVE TO INDUCE APOPTOSIS IN LEUKEMIA AND BREAST TUMOR CELLS. | PARKER HUGHES INSTITUTE | 2001-07-17 | — | — | US | claimed |