Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7975645 | 0.98 | ALDH1A1 (0.40) | MAPTGAATSHRALDH1A1NPSR1 | |
| SCHEMBL11549097 | 0.85 | HPGD (0.39) | MAPTGAATSHRALDH1A1NPSR1 | |
| SCHEMBL11552403 | 0.84 | ALDH1A1 (0.40) | MAPTGAATSHRALDH1A1HPGD | |
| SCHEMBL6331933 | 0.78 | MAPT (0.62) | MAPTGAATSHRALDH1A1HPGD | |
| SCHEMBL28175738 | 0.76 | ALDH1A1 (0.39) | ALDH1A1HPGDRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL1819086 | 0.76 | MAPT (0.61) | MAPTGAATSHRALDH1A1HPGD | |
| SCHEMBL2223429 | 0.74 | TSHR (0.63) | MAPTGAATSHRALDH1A1L3MBTL1 | |
| SCHEMBL3635136 | 0.74 | TSHR (0.63) | MAPTGAATSHRALDH1A1L3MBTL1 | |
| SCHEMBL21925345 | 0.74 | ALDH1A1 (0.42) | MAPTGAATSHRALDH1A1HPGD | |
| SCHEMBL29109686 | 0.73 | ALDH1A1 (0.41) | MAPTGAATSHRALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281295-B1 | Enamines as vulcanization accelerators for natural or synthetic rubbers | GREAT LAKES CHEMICAL ITALIA S.R.L. (IT) | 2001-08-28 | — | — | US | claimed |
| US-6281295-B1 | Enamines as vulcanization accelerators for natural or synthetic rubbers | GREAT LAKES CHEMICAL ITALIA S.R.L. (IT) | 2001-08-28 | — | — | US | disclosed |
| EP-0735083-B1 | Enamines as vulcanization accelerators for natural or synthetic rubbers | GREAT LAKES CHEMICAL EUROP (CH) | 2000-02-09 | — | — | EP | disclosed |
| EP-0735083-A1 | Enamines as vulcanization accelerators for natural or synthetic rubbers | GREAT LAKES CHEMICAL ITALIA S.r.l. (IT) | 1996-10-02 | — | — | EP | disclosed |
| US-4080334-A | Intermediates in the total synthesis employing substituted isoxazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 1978-03-21 | — | — | US | disclosed |
| US-4044004-A | Total steroid synthesis employing substituted isoxazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 1977-08-23 | — | — | US | disclosed |
| US-3985771-A | Total steroid synthesis employing substituted isoxazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 1976-10-12 | — | — | US | disclosed |
| US-3984428-A | Isoxazolyl-substituted perhydrobenzindenes | HOFFMANN-LA ROCHE INC. (US) | 1976-10-05 | — | — | US | disclosed |
| US-3984427-A | Preparation of vinyl lactones and corresponding Mannich bases | HOFFMANN-LA ROCHE INC. (US) | 1976-10-05 | — | — | US | disclosed |