Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 12/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 6/20 | 0.34 |
| ▸ | AKT2 | P31751 | 6/20 | 0.34 |
| ▸ | PRCP | P42785 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7962233 | 0.85 | HTR1A (0.47) | HTR1ASLC6A4 | |
| SCHEMBL7962232 | 0.83 | HTR1A (0.34) | HTR1ASLC6A4AKT1AKT2 | |
| SCHEMBL7966967 | 0.82 | HTR1A (0.45) | HTR1ASLC6A4 | |
| SCHEMBL7966964 | 0.71 | HTR1A (0.65) | HTR1ASLC6A4 | |
| SCHEMBL7966021 | 0.71 | HTR1A (0.47) | HTR1ASLC6A4 | |
| SCHEMBL7966960 | 0.68 | HTR1A (0.46) | HTR1ASLC6A4 | |
| SCHEMBL7953373 | 0.64 | HTR1A (0.40) | HTR1ASLC6A4 | |
| SCHEMBL7964964 | 0.64 | HTR1A (0.47) | HTR1ASLC6A4 | |
| SCHEMBL7965932 | 0.62 | HTR1A (0.42) | HTR1ASLC6A4JAK1 | |
| SCHEMBL7965119 | 0.62 | OPRM1 (0.39) | HTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |