Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7962648 | 0.84 | ABCB1 (0.47) | HTR1AABCB1DRD2DRD4SLC6A4 | |
| SCHEMBL7953366 | 0.83 | HTR1A (0.43) | HTR1ASLC6A4 | |
| SCHEMBL7968250 | 0.83 | KCNA3 (0.38) | HTR1AOPRL1ABCB1LTA4HOPRM1 | |
| SCHEMBL7953961 | 0.83 | OPRM1 (0.43) | HTR1AOPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL7966027 | 0.82 | MAPT (0.37) | HTR1AOPRL1ABCB1OPRM1OPRD1 | |
| SCHEMBL7965521 | 0.82 | HCRTR1 (0.34) | OPRL1ABCB1LTA4HOPRM1OPRD1 | |
| SCHEMBL7962651 | 0.82 | HTR1A (0.44) | HTR1AOPRL1ABCB1LTA4HOPRM1 | |
| SCHEMBL7953383 | 0.82 | HTR1A (0.40) | HTR1AOPRM1DRD3SLC6A4 | |
| SCHEMBL7968932 | 0.81 | OPRM1 (0.35) | HTR1AOPRL1ABCB1OPRM1OPRD1 | |
| SCHEMBL7965358 | 0.81 | PRMT5 (0.36) | OPRL1ABCB1OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| WO-2000006166-A1 | 5-HT1F ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |
| EP-0976747-A2 | Use of 5HT-1F receptor antagonists for treating anxiety disorders | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |