Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 8/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 8/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 8/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 8/20 | 0.35 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.34 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.33 |
| ▸ | HTR1A | P08908 | 3/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7953961 | 0.89 | OPRM1 (0.43) | OPRM1OPRD1OPRK1OPRL1ITGA4 | |
| SCHEMBL7966027 | 0.86 | MAPT (0.37) | OPRM1OPRD1OPRK1OPRL1ABCB1 | |
| SCHEMBL8132545 | 0.86 | NOTUM (0.33) | OPRM1OPRD1OPRK1OPRL1ITGA4 | |
| SCHEMBL7965195 | 0.85 | MEN1 (0.38) | OPRM1OPRD1OPRK1OPRL1ITGA4 | |
| SCHEMBL7969551 | 0.84 | MEN1 (0.41) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL7953292 | 0.84 | MAPT (0.41) | OPRM1OPRD1OPRK1OPRL1NPC1 | |
| SCHEMBL7953343 | 0.84 | ALDH1A1 (0.46) | OPRM1OPRD1OPRK1OPRL1DRD2 | |
| SCHEMBL7968936 | 0.83 | ABCB1 (0.52) | OPRM1OPRD1OPRK1ABCB1HTR1A | |
| SCHEMBL7966948 | 0.83 | OPRM1 (0.39) | OPRM1OPRD1OPRK1OPRL1RAB9A | |
| SCHEMBL7965358 | 0.83 | PRMT5 (0.36) | OPRM1OPRD1OPRK1OPRL1ITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| WO-2000006166-A1 | 5-HT1F ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |
| EP-0976747-A2 | Use of 5HT-1F receptor antagonists for treating anxiety disorders | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |