Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.34 |
| ▸ | BCL2 | P10415 | 2/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 5/20 | 0.33 |
| ▸ | RXRA | P19793 | 5/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.33 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 3/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7953681 | 0.89 | ADRB2 (0.34) | PRMT5WDR77RXRBRXRAITGA4 | |
| SCHEMBL7966027 | 0.86 | MAPT (0.37) | HTR7ABCB1OPRM1OPRD1OPRK1 | |
| SCHEMBL7953961 | 0.84 | OPRM1 (0.43) | ITGA4ITGB7OPRM1OPRD1OPRK1 | |
| SCHEMBL7964779 | 0.84 | SMN1; SMN2 (0.43) | PRMT5WDR77HTR7 | |
| SCHEMBL7965363 | 0.83 | PRMT5 (0.48) | PRMT5WDR77ABCB1 | |
| SCHEMBL7968932 | 0.83 | OPRM1 (0.35) | ITGA4ITGB7ABCB1OPRM1OPRD1 | |
| SCHEMBL7969551 | 0.82 | MEN1 (0.41) | PRMT5WDR77CNR1CNR2OPRM1 | |
| SCHEMBL7969068 | 0.82 | LMNA (0.41) | PRMT5WDR77MCL1BCL2PPARG | |
| SCHEMBL7953292 | 0.82 | MAPT (0.41) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL8132545 | 0.82 | NOTUM (0.33) | ITGA4ITGB7OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| WO-2000006166-A1 | 5-HT1F ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |
| EP-0976747-A2 | Use of 5HT-1F receptor antagonists for treating anxiety disorders | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |