Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 5/20 | 0.41 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | GLA | P06280 | 2/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7952723 | 0.88 | CYP11B2 (0.43) | CYP11B2KDM4ERXFP1GLACYP11B1 | |
| SCHEMBL7961492 | 0.85 | CYP11B2 (0.43) | CYP11B2KDM4ERXFP1CYP11B1MAOA | |
| SCHEMBL2158233 | 0.82 | CYP11B2 (0.42) | CYP11B2KDM4ERXFP1GLACYP11B1 | |
| SCHEMBL7964071 | 0.82 | CYP11B2 (0.39) | CYP11B2SQORCYP11B1MAPK1CYP3A4 | |
| SCHEMBL7962090 | 0.82 | CYP11B2 (0.39) | CYP11B2KDM4ERXFP1GLACYP11B1 | |
| SCHEMBL7962951 | 0.80 | CYP11B2 (0.37) | CYP11B2CYP11B1HTTCYP3A4CYP19A1 | |
| SCHEMBL7961877 | 0.80 | CYP11B2 (0.40) | CYP11B2KDM4ERXFP1GLACYP11B1 | |
| SCHEMBL8327786 | 0.80 | CYP11B2 (0.37) | CYP11B2CYP11B1HTTCYP3A4CYP19A1 | |
| SCHEMBL7964018 | 0.79 | GABRA1 (0.40) | CYP11B2CYP11B1POLBMAPK1CYP3A4 | |
| SCHEMBL7962850 | 0.79 | MKNK1 (0.41) | CYP11B2CYP11B1CYP3A4CYP19A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | claimed |
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | disclosed |