Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | DRD1 | P21728 | 1/20 | 0.58 |
| ▸ | DRD4 | P21917 | 1/20 | 0.58 |
| ▸ | DRD5 | P21918 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 5/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 6/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | HRH1 | P35367 | 2/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963733 | 0.81 | HTR7 (0.54) | DRD2DRD1DRD4DRD5TSHR | |
| Irampanel SCHEMBL678128 | 0.80 | HTR7 (0.63) | MAPK1L3MBTL1TDP1LMNAKDM4E | |
| Irampanel SCHEMBL6879876 | 0.79 | HTR7 (0.62) | MAPK1L3MBTL1TDP1LMNAKDM4E | |
| SCHEMBL7947527 | 0.78 | RAB9A (0.57) | TSHRMAPK1L3MBTL1TDP1LMNA | |
| SCHEMBL7957012 | 0.77 | NPC1 (0.49) | TSHRMAPK1L3MBTL1TDP1LMNA | |
| SCHEMBL7947228 | 0.76 | HTR1A (0.73) | TSHRMAPK1L3MBTL1TDP1NPC1 | |
| SCHEMBL5736045 | 0.75 | HTR7 (0.63) | TSHRL3MBTL1KDM4ENPC1RAB9A | |
| Phenyltoloxamine SCHEMBL5145512 | 0.74 | DRD1 (1.00) | DRD2DRD1DRD4DRD5TSHR | |
| Phenyltoloxamine SCHEMBL28854 | 0.74 | DRD1 (1.00) | DRD2DRD1DRD4DRD5TSHR | |
| SCHEMBL7958685 | 0.73 | NR1H4 (0.62) | LMNAKDM4ENPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6277872-B1 | ANTIISCHEMIC AGENTS; BRAIN DISORDERS | BOEHRINGER INGELHEIM KG (DE) | 2001-08-21 | — | — | US | disclosed |