Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 7/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CBFB | Q13951 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4420446 | 0.80 | ALDH1A1 (0.55) | TDP1MAPTMEN1POLBKMT2A | |
| SCHEMBL1013125 | 0.79 | PARP1 (0.59) | TDP1GAAMAPTMEN1POLB | |
| SCHEMBL23122996 | 0.79 | NQO2 (0.38) | GAAPARP1HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL3962251 | 0.79 | ALOX15 (0.37) | GAAPARP1HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL8014752 | 0.79 | MGAM (0.43) | GAAMAPTPARP1HPGDALDH1A1 | |
| Hydrochloric Acid SCHEMBL6120896 | 0.78 | PARP1 (0.57) | TDP1GAAMAPTMEN1POLB | |
| SCHEMBL3974201 | 0.76 | CBFB (0.44) | GAAMEN1KMT2APARP1HPGD | |
| Dimethylamine SCHEMBL7481385 | 0.75 | PARP1 (0.54) | TDP1GAAMAPTMEN1POLB | |
| SCHEMBL30291834 | 0.75 | MEN1 (0.58) | TDP1GAAMAPTMEN1POLB | |
| SCHEMBL3287778 | 0.75 | MEN1 (0.58) | TDP1GAAMAPTMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |