Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | LIG1 | P18858 | 1/20 | 0.35 |
| ▸ | RHOA | P61586 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4018484 | 0.78 | PKM (0.49) | PKMSMN1; SMN2ALDH1A1HSD17B10TSHR | |
| SCHEMBL4012449 | 0.78 | PKM (0.49) | PKMSMN1; SMN2ALDH1A1HSD17B10TSHR | |
| SCHEMBL10813508 | 0.77 | TSHR (0.36) | SMN1; SMN2ALDH1A1HSD17B10TSHRMAPK1 | |
| SCHEMBL10511460 | 0.77 | ALDH1A1 (0.40) | PKMSMN1; SMN2ALDH1A1HSD17B10TSHR | |
| SCHEMBL29225340 | 0.74 | ALDH1A1 (0.64) | ALDH1A1MAPK1MEN1KMT2ALMNA | |
| SCHEMBL4802900 | 0.74 | TSHR (0.45) | SMN1; SMN2ALDH1A1HSD17B10TSHRALOX15 | |
| SCHEMBL1325170 | 0.73 | CYP3A4 (0.56) | CYP3A4SMN1; SMN2ALDH1A1HSD17B10TSHR | |
| SCHEMBL17386357 | 0.73 | CYP3A4 (0.50) | CYP3A4NPSR1PKMSMN1; SMN2ALDH1A1 | |
| SCHEMBL203679 | 0.73 | ALDH1A1 (0.61) | CYP3A4NPSR1PKMSMN1; SMN2ALDH1A1 | |
| SCHEMBL17226138 | 0.72 | GAA (0.35) | CYP3A4PKMSMN1; SMN2ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0213506-B1 | Saturated cycloalkyl[c]pyrrole-2(1H)-acetic acid amides and derivatives thereof | WARNER-LAMBERT COMPANY (US) | 1989-02-15 | — | — | EP | claimed |
| EP-0213506-A1 | Saturated cycloalkyl[c]pyrrole-2(1H)-acetic acid amides and derivatives thereof | WARNER-LAMBERT COMPANY (US) | 1987-03-11 | — | — | EP | claimed |
| US-6255490-B1 | TREATING DISORDERS ASSOCIATED WITH CHANGES IN CHOLINERGIC ACTIVITY; NON-OPIATE BASED ANALGESIC FOR MODERATE TO SEVERE PAIN EQUALLY OR EXCEEDING THE POTENCY OF OPIATE ANALGESICS, YET LACKING ADDICTIVE SIDE EFFECTS | UNIVERSITY OF VIRGINIA | 2001-07-03 | — | — | US | disclosed |
| US-6117889-A | 7-Azabicyclo-[2.2.1]-heptane and -heptene derivatives as analgesics and anti-inflammatory agents | UNIVERSITY OF VIRGINIA (US) | 2000-09-12 | — | — | US | disclosed |
| US-6060473-A | 7-azabicyclo[2.2.1]-heptane and -heptene derivatives as cholinergic receptor ligands | UCB S.A. - DTB (BE) | 2000-05-09 | — | — | US | disclosed |
| EP-0778835-A4 | 7-AZABICYCLO 2.2.1]-HEPTANE AND -HEPTENE DERIVATIVES AS CHOLINERGIC RECEPTOR LIGANDS | UNIV VIRGINIA (US) | 1999-02-03 | — | — | EP | disclosed |
| US-5817679-A | ANALGESICS, ANTIINFLAMMATORY AGENTS | UNIVERSITY OF VIRGINIA (US) | 1998-10-06 | — | — | US | disclosed |
| EP-0778835-A1 | 7-AZABICYCLO 2.2.1]-HEPTANE AND -HEPTENE DERIVATIVES AS CHOLINERGIC RECEPTOR LIGANDS | UNIVERSITY OF VIRGINIA (US) | 1997-06-18 | — | — | EP | disclosed |
| WO-1996006093-A1 | 7-AZABICYCLO[2.2.1]-HEPTANE AND -HEPTENE DERIVATIVES AS CHOLINERGIC RECEPTOR LIGANDS | UNIVERSITY OF VIRGINIA (US) | 1996-02-29 | — | — | WO | disclosed |
| EP-0691971-A1 | 7-AZABICYCLO- 2.2.1]-HEPTANE AND -HEPTENE DERIVATIVES AS ANALGESICS AND ANTI-INFLAMMATORY AGENTS | UNIVERSITY OF VIRGINIA (US) | 1996-01-17 | — | — | EP | disclosed |
| WO-1994022868-A1 | 7-AZABICYCLO-[2.2.1]-HEPTANE AND -HEPTENE DERIVATIVES AS ANALGESICS AND ANTI-INFLAMMATORY AGENTS | UNIVERSITY OF VIRGINIA (US) | 1994-10-13 | — | — | WO | disclosed |
| EP-0213506-B1 | Saturated cycloalkyl[c]pyrrole-2(1H)-acetic acid amides and derivatives thereof | WARNER-LAMBERT COMPANY (US) | 1989-02-15 | — | — | EP | disclosed |
| EP-0213506-A1 | Saturated cycloalkyl[c]pyrrole-2(1H)-acetic acid amides and derivatives thereof | WARNER-LAMBERT COMPANY (US) | 1987-03-11 | — | — | EP | disclosed |
| US-4621097-A | COGNITION ACTIVATORS | WARNER-LAMBERT COMPANY (US) | 1986-11-04 | — | — | US | disclosed |
| US-4528382-A | Imidoyl substituted pyrroles | MCNEILAB, INC. (US) | 1985-07-09 | — | — | US | disclosed |
| US-4528382-A | Imidoyl substituted pyrroles | MCNEILAB, INC. (US) | 1985-07-09 | — | — | US | disclosed |