Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | AR | P10275 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 7/20 | 0.50 |
| ▸ | NPC1 | O15118 | 6/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.50 |
| ▸ | RELA | Q04206 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7964121 | 1.00 | SMN1; SMN2 (0.61) | SMN1; SMN2ARKMT2ALMNAMAPT | |
| SCHEMBL8501939 | 0.84 | RAB9A (0.68) | SMN1; SMN2ARKMT2ALMNAMAPT | |
| SCHEMBL7974431 | 0.84 | SMN1; SMN2 (0.55) | SMN1; SMN2ARKMT2ALMNAMAPT | |
| SCHEMBL7974426 | 0.84 | SMN1; SMN2 (0.55) | SMN1; SMN2ARKMT2ALMNAMAPT | |
| SCHEMBL7964060 | 0.82 | SMN1; SMN2 (0.62) | SMN1; SMN2ARKMT2ALMNAMAPT | |
| SCHEMBL5352269 | 0.81 | RAB9A (0.72) | SMN1; SMN2ARKMT2ALMNAMAPT | |
| SCHEMBL8503121 | 0.81 | RAB9A (0.66) | SMN1; SMN2ARKMT2ALMNAMAPT | |
| SCHEMBL7963873 | 0.80 | SMN1; SMN2 (0.60) | SMN1; SMN2ARKMT2ALMNAMAPT | |
| SCHEMBL7964031 | 0.80 | SMN1; SMN2 (0.60) | SMN1; SMN2ARKMT2ALMNAMAPT | |
| SCHEMBL31515434 | 0.80 | CYP2C9 (0.74) | SMN1; SMN2ARKMT2ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | claimed |
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | disclosed |