Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.62 |
| ▸ | RAB9A | P51151 | 11/20 | 0.53 |
| ▸ | NPC1 | O15118 | 9/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.53 |
| ▸ | RELA | Q04206 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | AR | P10275 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2992917 | 0.83 | RAB9A (0.72) | SMN1; SMN2RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL7964031 | 0.83 | SMN1; SMN2 (0.60) | SMN1; SMN2RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL8980114 | 0.82 | RAB9A (0.55) | SMN1; SMN2RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL7964121 | 0.82 | SMN1; SMN2 (0.61) | SMN1; SMN2RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL7964010 | 0.82 | SMN1; SMN2 (0.61) | SMN1; SMN2RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL7963873 | 0.81 | SMN1; SMN2 (0.60) | SMN1; SMN2RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL7977579 | 0.80 | RAB9A (0.66) | SMN1; SMN2RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL7977643 | 0.79 | AR (0.43) | SMN1; SMN2RAB9AALDH1A1HPGDPOLB | |
| SCHEMBL7977639 | 0.77 | RAB9A (0.59) | SMN1; SMN2RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL7980296 | 0.77 | SMN1; SMN2 (0.57) | SMN1; SMN2RAB9ANPC1NFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | claimed |
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | disclosed |