Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 4/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963787 | 0.90 | HTR1A (0.48) | SIGMAR1DRD2HTR1APARP1HTR7 | |
| SCHEMBL7961371 | 0.89 | SIGMAR1 (0.50) | SIGMAR1DRD2HTR1A | |
| SCHEMBL7961484 | 0.89 | SIGMAR1 (0.55) | SIGMAR1DRD2HTR1A | |
| SCHEMBL7959610 | 0.88 | SIGMAR1 (0.48) | SIGMAR1DRD2HTR1A | |
| SCHEMBL7963865 | 0.87 | SIGMAR1 (0.46) | SIGMAR1DRD2HTR1AHTR7LMNA | |
| SCHEMBL7957217 | 0.86 | SIGMAR1 (0.52) | SIGMAR1HTR1APARP1 | |
| SCHEMBL7961332 | 0.84 | HTR1A (0.53) | SIGMAR1DRD2HTR1APARP1HTR7 | |
| SCHEMBL7957391 | 0.82 | HTR7 (0.47) | SIGMAR1DRD2HTR1APARP1HTR7 | |
| SCHEMBL7964089 | 0.81 | DRD2 (0.64) | SIGMAR1DRD2HTR1APARP1CYP2D6 | |
| SCHEMBL7949602 | 0.81 | DRD2 (0.44) | SIGMAR1DRD2HTR1AHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |