Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7959188 | 0.90 | HPGD (0.51) | HPGDSIGMAR1KDM4EL3MBTL1CHRM2 | |
| SCHEMBL7949039 | 0.90 | SIGMAR1 (0.53) | HPGDSIGMAR1HTR1APARP1HTT | |
| SCHEMBL7957285 | 0.90 | SIGMAR1 (0.53) | SIGMAR1PARP1MAPK1NPSR1POLB | |
| SCHEMBL7959719 | 0.90 | SIGMAR1 (0.55) | SIGMAR1KDM4EL3MBTL1HTR1APARP1 | |
| SCHEMBL7960931 | 0.86 | SIGMAR1 (0.56) | HPGDSIGMAR1CHRM2HTR1AADRA2A | |
| SCHEMBL7959347 | 0.84 | LMNA (0.45) | HPGDSIGMAR1PARP1POLBLMNA | |
| SCHEMBL7949425 | 0.84 | LMNA (0.52) | HPGDSIGMAR1PARP1POLBLMNA | |
| SCHEMBL7949533 | 0.84 | GAA (0.50) | HPGDSIGMAR1PARP1POLB | |
| SCHEMBL7958937 | 0.82 | PKM (0.52) | HPGDSIGMAR1KDM4EL3MBTL1CHRM2 | |
| SCHEMBL7961207 | 0.81 | POLB (0.44) | SIGMAR1KDM4EL3MBTL1CHRM2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |