Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.40 |
| ▸ | PARP1 | P09874 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7949425 | 0.93 | LMNA (0.52) | LMNASHMT2HPGDMEN1KMT2A | |
| SCHEMBL7957285 | 0.87 | SIGMAR1 (0.53) | LMNAMEN1KMT2ASIGMAR1PARP1 | |
| SCHEMBL7949039 | 0.87 | SIGMAR1 (0.53) | HPGDSIGMAR1PARP1GAADRD2 | |
| SCHEMBL7959188 | 0.85 | HPGD (0.51) | LMNAHPGDSIGMAR1GAAPOLB | |
| SCHEMBL7949533 | 0.85 | GAA (0.50) | HPGDSIGMAR1PARP1GAASMN1; SMN2 | |
| SCHEMBL7964099 | 0.84 | HPGD (0.53) | LMNAHPGDSIGMAR1PARP1HTT | |
| SCHEMBL7960974 | 0.83 | LMNA (0.45) | LMNASHMT2HPGDSIGMAR1PARP1 | |
| SCHEMBL7960931 | 0.83 | SIGMAR1 (0.56) | HPGDSIGMAR1PARP1POLB | |
| SCHEMBL7963975 | 0.81 | L3MBTL1 (0.39) | LMNASHMT2HPGDMEN1KMT2A | |
| SCHEMBL7959719 | 0.81 | SIGMAR1 (0.55) | LMNAMEN1KMT2ASIGMAR1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |