Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 14/20 | 0.48 |
| ▸ | DRD2 | P14416 | 8/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2434032 | 1.00 | DRD4 (0.48) | DRD4DRD2SLC6A4GAA | |
| SCHEMBL7974740 | 1.00 | DRD4 (0.48) | DRD4DRD2SLC6A4GAA | |
| SCHEMBL3363237 | 0.79 | MGAM (0.45) | SLC6A4GAA | |
| SCHEMBL7977155 | 0.79 | DRD4 (0.44) | DRD4DRD2SLC6A4 | |
| SCHEMBL2438157 | 0.79 | DRD4 (0.44) | DRD4DRD2SLC6A4 | |
| SCHEMBL2433489 | 0.75 | DRD4 (0.43) | DRD4DRD2SLC6A4 | |
| SCHEMBL7974742 | 0.75 | DRD4 (0.43) | DRD4DRD2SLC6A4 | |
| SCHEMBL7963848 | 0.74 | SLC6A4 (0.60) | DRD4DRD2SLC6A4 | |
| SCHEMBL2433288 | 0.74 | SLC6A4 (0.60) | DRD4DRD2SLC6A4 | |
| SCHEMBL12293338 | 0.72 | SLC6A4 (0.49) | DRD4DRD2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110230428-A1 | CERTAIN KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF | CHDI FOUNDATION, INC. | 2011-09-22 | — | — | US | disclosed |
| US-20110230428-A1 | CERTAIN KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF | CHDI FOUNDATION, INC. | 2011-09-22 | — | — | US | disclosed |
| WO-2010011302-A1 | CERTAIN KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF | CHDI, INC. (US) | 2010-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230428-A1 | CERTAIN KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF | KMO, KYNU, MAOA | DRD4 3036/4885DRD2 2185/4885SLC6A4 670/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.