Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8019949 | 0.91 | L3MBTL1 (0.37) | MAPTL3MBTL1LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL8132545 | 0.90 | NOTUM (0.33) | MAPTL3MBTL1PDPK1GAAOPRM1 | |
| SCHEMBL7962723 | 0.89 | MAP4K4 (0.36) | MAPTPDPK1GAAKMT2AMEN1 | |
| SCHEMBL7966948 | 0.88 | OPRM1 (0.39) | LMNASMN1; SMN2ALDH1A1KDM4EOPRM1 | |
| SCHEMBL7966027 | 0.87 | MAPT (0.37) | MAPTLMNAGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL7953681 | 0.87 | ADRB2 (0.34) | LMNAKDM4EOPRM1OPRD1OPRK1 | |
| SCHEMBL7964370 | 0.87 | ABCB1 (0.43) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL7953961 | 0.86 | OPRM1 (0.43) | MAPTLMNAGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL7969474 | 0.84 | MAPT (0.38) | MAPTLMNASMN1; SMN2ALDH1A1OPRM1 | |
| SCHEMBL7968932 | 0.84 | OPRM1 (0.35) | OPRM1OPRD1OPRK1OPRL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |
| EP-0976747-A2 | Use of 5HT-1F receptor antagonists for treating anxiety disorders | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |