Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 8/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD5 | P21918 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.31 |
| ▸ | PTPRC | P08575 | 1/20 | 0.30 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.30 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
| ▸ | PTPRB | P23467 | 1/20 | 0.30 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.30 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.30 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7849178 | 0.78 | ALDH1A1 (0.50) | DRD2DRD4DRD3GAAMAPT | |
| SCHEMBL7682354 | 0.78 | DRD1 (0.50) | DRD1DRD2DRD4DRD5DRD3 | |
| SCHEMBL7850916 | 0.74 | CYP1A2 (0.43) | KDM4ELMNAGAAMAPTL3MBTL1 | |
| SCHEMBL3135214 | 0.73 | CYP1A2 (0.55) | LMNAGAAMAPTL3MBTL1TDP1 | |
| SCHEMBL7849235 | 0.73 | HTR2C (0.41) | KDM4ELMNAGAAMAPTCYP1A2 | |
| Bromide SCHEMBL29185181 | 0.72 | CA1 (0.52) | DRD2DRD3KDM4ELMNAMAPT | |
| SCHEMBL7848646 | 0.72 | CYP1A2 (0.49) | LMNAMAPTL3MBTL1TDP1PTPN11 | |
| SCHEMBL10913428 | 0.71 | DRD1 (0.40) | DRD1DRD2DRD4DRD5DRD3 | |
| SCHEMBL7849725 | 0.71 | LMNA (0.50) | LMNAMAPTL3MBTL1PTPN11CYP1A2 | |
| SCHEMBL809133 | 0.70 | CA1 (0.55) | DRD2DRD3KDM4ELMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6169184-B1 | REACTING SUBSTITUTED PYRIDINE WITH SPECIFIED ARYL COMPOUND | BASF AKTIENGESELLSCHAFT (DE) | 2001-01-02 | — | — | US | disclosed |