Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | GLA | P06280 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.39 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.36 |
| ▸ | CHRNB1 | P11230 | 3/20 | 0.36 |
| ▸ | CHRNB3 | Q05901 | 3/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.35 |
| ▸ | CHRNA2 | Q15822 | 2/20 | 0.35 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.35 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7961438 | 0.87 | CYP11B2 (0.41) | CYP11B2KDM4EGLACHRNB2CHRNB4 | |
| SCHEMBL7967494 | 0.86 | CYP11B2 (0.41) | CYP11B2KDM4ERXFP1CHRNB2CHRNB4 | |
| SCHEMBL2158211 | 0.84 | KMT2A (0.40) | CYP11B2KDM4EGLARXFP1CHRNB2 | |
| SCHEMBL7961681 | 0.83 | CYP11B2 (0.37) | CYP11B2KDM4EGLACYP11B1MAOA | |
| SCHEMBL8328648 | 0.82 | KDM4E (0.38) | CYP11B2KDM4ENPSR1CHRNB2CHRNB4 | |
| SCHEMBL7967855 | 0.82 | UCHL1 (0.40) | CYP11B2KDM4ECYP11B1ALDH1A1UCHL1 | |
| SCHEMBL7963297 | 0.81 | MKNK1 (0.42) | CYP11B2KDM4ENPSR1CHRNB2CHRNB4 | |
| SCHEMBL7952536 | 0.81 | ALDH1A1 (0.40) | CYP11B2KDM4ENPSR1CYP11B1ALDH1A1 | |
| SCHEMBL7965300 | 0.81 | KCNMA1 (0.34) | CYP11B2SQORCHRNB4CHRNA3USP30 | |
| SCHEMBL7961349 | 0.81 | KCNMA1 (0.34) | KDM4ECHRNB4CHRNA3MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | claimed |
| EP-0946555-A1 | PYRROLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Aventis Pharma S.A. (FR) | 1999-10-06 | — | — | EP | claimed |
| WO-1998025925-A1 | PYRROLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | RHONE-POULENC RORER S.A. (FR) | 1998-06-18 | — | — | WO | claimed |
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | disclosed |
| EP-0946555-A1 | PYRROLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Aventis Pharma S.A. (FR) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998025925-A1 | PYRROLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | RHONE-POULENC RORER S.A. (FR) | 1998-06-18 | — | — | WO | disclosed |