Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSPO | P30536 | 2/20 | 0.54 |
| ▸ | FABP4 | P15090 | 1/20 | 0.46 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.45 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 4/20 | 0.43 |
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7966547 | 0.91 | TSPO (0.54) | TSPODCTPP1TBXA2RMAPTKDM4E | |
| SCHEMBL7954430 | 0.87 | PARP1 (0.52) | TSPOFABP4DCTPP1TBXA2RCHRM1 | |
| SCHEMBL7483323 | 0.85 | TSPO (0.47) | TSPOFABP4DCTPP1TBXA2RCHRM1 | |
| SCHEMBL8601846 | 0.80 | PPARG (0.48) | TSPOFABP4DCTPP1TBXA2RCHRM1 | |
| SCHEMBL7966864 | 0.77 | PARP1 (0.51) | TSPODCTPP1USP2TP53KDM4E | |
| SCHEMBL7427558 | 0.77 | TSPO (0.47) | TSPODCTPP1TBXA2RMAPTUSP2 | |
| SCHEMBL7966866 | 0.69 | CCR2 (0.46) | TSPODCTPP1CCR2USP2TP53 | |
| SCHEMBL6953212 | 0.69 | PPARG (0.50) | DCTPP1TBXA2RPPARGUSP2KDM4E | |
| SCHEMBL3116842 | 0.68 | CHRM1 (0.52) | FABP4CHRM1MAPTUSP2TP53 | |
| SCHEMBL8600049 | 0.68 | KDM4E (0.51) | TSPODCTPP1TBXA2RPPARGUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |