Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 2/20 | 0.46 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.45 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.43 |
| ▸ | ERCC5 | P28715 | 3/20 | 0.43 |
| ▸ | TSPO | P30536 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CASP1 | P29466 | 2/20 | 0.42 |
| ▸ | CASP7 | P55210 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | DCTPP1 | Q9H773 | 3/20 | 0.42 |
| ▸ | FEN1 | P39748 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7954430 | 0.81 | PARP1 (0.52) | CCR2TSPOKDM4EALDH1A1GLA | |
| SCHEMBL1081597 | 0.80 | PLA2G2A (0.45) | PLA2G2AALDH1A1 | |
| SCHEMBL7966864 | 0.76 | PARP1 (0.51) | TSPOKDM4EALDH1A1GLAGAA | |
| SCHEMBL1080660 | 0.70 | EGLN3 (0.47) | PLA2G2AKDM4EALDH1A1GLAGAA | |
| SCHEMBL7965376 | 0.69 | TSPO (0.54) | CCR2TSPOKDM4EALDH1A1USP2 | |
| SCHEMBL7483323 | 0.69 | TSPO (0.47) | CCR2TSPOKDM4EALDH1A1GLA | |
| SCHEMBL11419391 | 0.68 | ALDH1A1 (0.45) | CCR2TSPOKDM4EALDH1A1GLA | |
| SCHEMBL1080943 | 0.67 | TNF (0.47) | PLA2G2AKDM4EALDH1A1GAAHPGD | |
| SCHEMBL8601853 | 0.67 | DCTPP1 (0.45) | CCR2P2RX3ERCC5KDM4EALDH1A1 | |
| SCHEMBL2579724 | 0.65 | KLKB1 (0.43) | CCR2P2RX3ERCC5KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |